Viagra Lowers High Blood Pressure
Are you having erectile dysfunctions? Use Viagra. Are you hypertensive? Use
Viagra. Although the answer to the second question might seem strange to some,
apparently it’s nevertheless true. The drug that gives older men a few
moments of pleasure
can also be used to lower blood pressure.
Baltimore researchers said while Viagra, sildenafil citrate, is more widely
known for helping genital blood vessels expand to maintain an erection and,
more recently, as a treatment for pulmonary hypertension, it has been thought
to have little direct effect on the human heart.
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The recent study suggests that sildenafil weakens the strengthened heart beat
caused by chemically induced stress, thereby lessening the excess amount of
blood and force used to pump it to the body, according to study senior author
Dr. David Kass, a Johns Hopkins cardiology professor.
Under normal conditions, say the researchers, Viagra has no effect on the heart
- it is only when the heart is under stress and pumping with more power.
This study involved 35 healthy men. They were given dobutamine injections,
two of them in three-hour intervals. Dobutamine chemically stresses the heart,
making it pump harder. After the first injection the men's heart contractions
increased in force by 150%.
Some patients were given Viagra while others were given a placebo (dummy drug)
between the two dobutamine injections. Those given Viagra experienced a 50%
drop in heartbeat strength.
Viagra in Heart Disease
Most men with heart disease can take sildenafil safely
By DrRich
Viagra (sildenafil) has revolutionized the treatment of male sexual dysfunction.
However, its use has been said to be dangerous in patients with certain types
of heart disease. The purpose of this article is to review the safe use of sildenafil
in men with heart disease.
Sildenafil has two actions that may be of consequence in patients with heart
disease. First, it can lower the blood pressure. Second, it interacts with nitrates.
Sildenafil is a vasodilator (that is, a drug that dilates blood vessels), and
consequently it lowers the systolic blood pressure (the "top" number
in blood pressure measurements) by an average of 8 mmHg. In the majority of
patients with heart disease, including most of those being treated with antihypertensive
drugs, this is not a problem. Studies have shown that the incidence of side
effects (including side effects related to low blood pressure, such as dizziness
and fainting) are no higher in users of sildenafil who are also taking antihypertensive
drugs.
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However, the vasodilating effects of sildenafil do become potentially hazardous
when combined with the vasodilating effects of nitrates, drugs that are still
commonly used in patients with coronary artery disease. Patients taking both
nitrates and sildenafil are prone to develop severe hypotension (low blood pressure)
and syncope (fainting.) Patients taking nitrates for their coronary artery disease,
therefore, should never take sildenafil. Further, anyone who has taken sildenafil
during the past 24 hours should not take nitrates.
When sildenafil was first introduced in the late 1990s, reports of heart attack
and sudden death after taking the drug appeared all over the news. Subsequent
studies have suggested that, in patients not taking nitrates, the use of
sildenafil in patients with stable coronary artery disease does not cause an
increased risk of heart attack or death. While these events indeed occur in
patients with coronary artery disease, their incidence is no higher in patients
taking sildenafil.
Indeed, sildenafil appears to be quite well tolerated in men with even severe
coronary artery disease, as long as they do not have active ischemia (periods
of time where the heart muscle is not getting appropriate blood flow, most often
manifested by chest pain) and are not taking nitrates. Further, sildenafil
does not increase the risk of exercise in patients with stable coronary artery
disease.
There are some conditions in which the modest drop in systolic blood pressure
caused by sildenafil may be dangerous. Patients with severe heart failure accompanied
by low blood pressure measurements may become worse if further hypotension is
produced. In addition, some patients with hypertrophic cardiomyopathy may
become symptomatic if their systolic blood pressure is reduced.
The bottom line
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The American College of Cardiology and the American Heart Association concur
that sildenafil is safe for men with stable coronary artery disease who are
not taking nitrates, but should never be used in patients who are taking nitrates.
(Nitrates include all forms of nitroglycerin - sublingual, transdermal and spray
forms - as well as isosorbide mononitrate, isosorbide dinitrate, pentaerythritol
tetranitrate, erythrityl tetranitrate, and amyl nitrate.)
It should be noted that, while in the past nitrates were the foundation of
therapy for coronary artery disease, this is no longer the case. In the era
of angioplasty and stenting, coronary artery disease is usually manageable without
resorting to nitrates. Patients who are being prescribed nitrates and wish to
take sildenafil should ask your doctors about alternate forms of therapy for
their coronary artery disease.
There are other groups of heart patients for whom sildenafil may be potentially
dangerous. These include patients with unstable coronary artery disease or active
coronary artery ischemia (i.e., patients whose coronary artery disease is not
stable.) These patients, obviously, have an active medical problem that needs
to be stabilized whether or not sildenafil is being considered. Once they are
sufficiently treated, the use of sildenafil (as well as all other forms of routine,
daily life such as exercise) can be entertained.
Other patients who may have trouble with sildenafil are those with heart failure
accompanied by borderline low blood pressure, some patients with hypertrophic
cardiomyopathy, and possibly, patients on complicated drug regimens for hypertension.
With these exceptions, sildenafil can be used safely in the vast majority
of patients with heart disease.
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